Senator Loeffler was sworn in on January 6, 2020, having been appointed by Georgia Governor Brian Kemp to fill retiring Senator Johnny Isakson’s seat. Senator Loeffler participated in debate on the Senate floor in favor of S. 311, the Born-Alive Abortion Survivors Protection Act and S. 3275, the Pain-Capable Unborn Child Protection Act. She introduced S. 3388, the Woman's Right to Know Act, and led Congressional letters calling on the Department of the Treasury and Department of Justice to investigate abuses by Planned Parenthood.