Senator Hyde-Smith has stood up against extremist nominees of the pro-abortion Biden-Harris administration, against pro-abortion action both in the administration and through legislation advanced by Majority Leader Chuck Schumer. Sen. Hyde-Smith has voted consistently to defend the lives of the unborn and infants. This includes stopping hard-earned tax dollars from paying for abortion, whether domestically or internationally, and protecting health care provider rights for those who refuse to engage in brutal abortions.

Senator Hyde-Smith introduced S. 78, the SAVE Moms and Babies Act, which would prohibit the Food and Drug Administration (FDA) from approving any new abortion drugs or from weakening current restrictions on the dangerous drugs. She also introduced S.77, the Protecting Life and Integrity in Research Act, which would prohibit the U.S. Department of Health & Human Services from conducting any research using human fetal tissue from an induced abortion. Sen. Hyde-Smith led a letter urging the FDA to enforce longstanding safety regulations on abortion drugs and to end dangerous runarounds of these protections under the guise of medical research. She co-led a public comment letter asking HHS Secretary Xavier Becerra to withdraw the Biden administration's proposed rule to eliminate a 2019 Trump-era rule requiring separate payments for abortion coverage in taxpayer-funded Obamacare exchange plans. She also introduced an amendment to S. Con. Res. 5, the Budget Resolution, that would stop the expansion of chemical abortion drugs at the federal level. Along with the rest of the Mississippi delegation and Congressman Chris Smith, Sen. Hyde-Smith co-led the pro-life congressional amicus brief in the Dobbs v. Jackson Women's Health Organization late-term abortion Supreme Court case, and hosted Mississippi Attorney General and pro-life leaders in senator briefings related to the SCOTUS late abortion case. Representing Mississippi, she spoke outside the Supreme Court at the pro-life rally on the day of Dobbs oral arguments and gave speeches defending life during a Senate press conference and colloquy on the eve of oral arguments in the Dobbs Supreme Court case. She sent a letter demanding that Google stop silencing pro-life views and reverse unjust censorship, and co-led bicameral letters supporting ethical standards regarding human fetal tissue and opposing the FDA's decision to make chemical abortion more easily accessible during the pandemic.

Senator Hyde-Smith has voted consistently to protect the lives of unborn babies and infants as well as the consciences of taxpayers who don’t want their hard-earned tax dollars paying for abortion domestically or internationally. While the pro-abortion majority in the U.S. House of Representatives continually sends the Senate bills that roll back pro-life protections, the Senate has made it their priority to confirm judges and justices who will respect the constitution and leave legislating to the legislative branch.

Senator Hyde-Smith led efforts in the Senate throughout the year to push for the finalization of the abortion separate payments rule. She also introduced S. 3072, the Support and Value Expectant (SAVE) Moms and Babies Act. Sen. Hyde-Smith led a bicameral letter urging the FDA to uphold restrictions on chemical abortion, to protect women's health.